Effects of interhemispheric multi-target intermittent theta burst stimulation on upper limb function in patients with stroke
10.3969/j.issn.1006-9771.2022.05.002
- VernacularTitle:基于大脑半球之间多靶区间歇性θ爆发式磁刺激对脑卒中患者上肢功能的影响
- Author:
Zhigang CAO
1
;
Haixia FENG
1
;
Yabin LI
1
;
Jiali YANG
1
;
Jiao LI
1
;
Hongxia WANG
1
;
Boxuan QU
1
;
Yayun ZHANG
1
Author Information
1. Department of Neurology, Gansu Provine Hospital Rehabilitation Center, Lanzhou, Gansu 730000, China
- Publication Type:Journal Article
- Keywords:
stroke;
multiple target;
intermittent theta burst stimulation;
upper extremity
- From:
Chinese Journal of Rehabilitation Theory and Practice
2022;28(5):502-507
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of intermittent theta burst stimulation (iTBS) of the multi-target cerebral cortex after stroke on functional recovery of the upper limb of the hemiplegic side. MethodsFrom November, 2019 to August, 2020, 40 stroke patients in Gansu Provine Hospital Rehabilitation Center were included and randomly divided into single-target stimulation group (n = 20) and multiple-target stimulation group (n = 20). Both groups underwent basic neurorehabilitation drug therapy and conventional rehabilitation exercises. The single-target stimulation group received repetitive transcranial magnetic stimulation (rTMS) (iTBS mode) only in the primary motor cortex (M1) of the affected side. The multi-target stimulation group received rTMS (iTBS mode) in the cerebellar cortex of the healthy brain and M1 of the affected side, once a day, six days a week, for four weeks. Before and after treatment, the scores of Fugl-Meyer Assessment-Upper Extremities (FMA-UE), Action Research Arm Test (ARAT) and modified Barthel Index (MBI), and the latency and amplitude of somatosensory-evoked potentials N20 were compared. ResultsNo serious adverse reaction occurred during treatment. After treatment, the scores of FMA-UE, MBI and ARAT, and the amplitude and latency of N20 improved in both groups (|t| > 3.478, |Z| > 2.243, P < 0.05); and the scores of FMA-UE and ARAT, and the amplitude of N20 were better in the multiple-target stimulation group than in the single-target stimulation group (t > 2.939, Z = -2.697, P < 0.01). ConclusionMulti-target stimulation is superior to single-target stimulation for improving upper limb motor function and N20 amplitude in the hemiplegics after stroke.
