A Retrospective Study on the Low Dose Lamotrigine of Skin Disorders

Yosuke Morita; Kyohei Watanabe; Takaaki Kodawara; Yumi Tsubota; Ryoichi Yano; Hitoshi Tsukamoto; Nobuyuki Goto

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A Retrospective Study on the Low Dose Lamotrigine of Skin Disorders

VernacularTitle:ラモトリギンの低用量による皮膚障害に関する後ろ向き調査
Author: Yosuke MORITA ¹ ; Kyohei WATANABE ¹ ; Takaaki KODAWARA ² ; Yumi TSUBOTA ¹ ; Ryoichi YANO ¹ ; Hitoshi TSUKAMOTO ³ ; Nobuyuki GOTO ¹
Author Information

1. Department of Pharmacy, University of Fukui Hospital
2. Medical Research Support Center, University of Fukui Hospital
3. Education and Research Center for Clinical Pharmacy, Osaka University of Pharmaceutical Sciences
Keywords: lamotrigine; skin disorders; low-dose initiation; retrospective study
From:Japanese Journal of Drug Informatics 2022;23(4):178-182
CountryJapan
Language:Japanese
Abstract: Objective: In this study, we investigated the occurrence of skin damage following the initiation of low-dose lamotrigine.Methods: We retrospectively analyzed the incidence of skin disorders within 8 weeks of the start of lamotrigine administration, prescribing for 3 years from July 2014 to June 2016.In addition, we also confirmed the onset time of skin disorders in the low- and normal-dose groups.Results: The incidence of skin damage was 7.7 and 24.6 % in the low- and normal-dose lamotrigine start groups, respectively. The onset of skin disorders was relatively early in the normal-dose lamotrigine start group.On the other hand, no tendency was found in the low-dose lamotrigine start group because the number of cases was small.Conclusion: The initiation of low-dose lamotrigine and extension of introduction period might reduce the onset of early skin damage.