An Observational Study on the Safety of Long-term Intake of Coix-seed Reactive Derivatives (CRD) in Adults

VernacularTitle:ハトムギ全粒熱水抽出エキス(Coix-seed Reactive Derivatives: CRD) 長期摂取の安全性に関する臨床研究
Author: Nobutaka SUZUKI ¹ ; Hirotaka OKUWA-HAYASHI ² ; Hoko KYO ³
Author Information

1. Science Research Center of Alternative Medicine
2. The Faculty of Food Culture, Kurashiki Sakuyo University
3. Urata Clinic, Hospy Medical Association
Keywords: Coix lachryma-jobi L. var. ma-yuen Stapf; whole grain; hot water extract; Coix-seed Reactive Derivatives; CRD; safety; long-term safety; clinical research
From:Japanese Journal of Complementary and Alternative Medicine 2022;19(1):9-13
CountryJapan
Language:Japanese
Abstract: We evaluated the long-term safety of eight adult volunteers (male 7, female 1: average age 47.4 years) ingesting powdered foods containing Coix-seed Reactive Derivatives (CRD/2.2g/day or 4.4g/day) for 1 year 8 months to 5 years (average 2 years 9 months). Body weight, vital signs (blood pressure, pulse rate), peripheral blood test, blood biochemical test, etc. were observed. We also investigated the presence or absence of side effects. The results showed no notable changes in vital signs or blood test results. From the above, it was speculated that long-term intake of CRD would not pose a safety problem. We plan to continue the study by increasing the number of observation cases in the future.