A Preliminary Study for the Effect of Coix-seed Reactive Derivatives (CRD) on Human Skin Fibroblast Proliferation and Collagen Production
- VernacularTitle:ハトムギ全粒熱水抽出エキス(Coix-seed Reactive Derivatives:CRD)のヒト線維芽細胞増殖とコラーゲン産生に及ぼす影響
- Author:
Nobutaka SUZUKI
1
;
Hirotaka OKUWA-HAYASHI
2
;
Hoko KYO
3
Author Information
- Keywords: Coix lachryma-jobi L. var. ma-yuen Stapf; whole grain; hot water extract; Coix-seed Reactive Derivatives; CRD; wrinkles; fibroblast; collagen
- From:Japanese Journal of Complementary and Alternative Medicine 2022;19(1):61-64
- CountryJapan
- Language:Japanese
- Abstract: Objective: We investigated the effects of Coix-seed Reactive Derivatives (CRD) on fibroblast proliferation and collagen production. Methods: Various concentrations of CRD (0.00001%, 0.0001%, 0.001%, 0.01%, 0.1%, 1%) were added to human fibroblasts, and changes in cell count and extracellular collagen production were measured. Results: Fibroblasts proliferated by the addition of CRD, peaked at about 1.7 times when the CRD concentration was 0.0001%, and then decreased as the addition concentration increased. On the other hand, the collagen concentration in the extracellular matrix of fibroblasts increased as the CRD addition concentration increased, and the collagen concentration increased sharply at 0.1% of CRD concentration or more. Conclusion: It was suggested that CRD has a function of increasing the proliferation of fibroblasts and collagen production.
