Research progress on pharmacokinetics and toxicity of vinorelbine
- VernacularTitle:长春瑞滨药动学及毒副作用研究进展
- Author:
Hua LIU
1
;
Yanshen CHEN
1
;
Huining YOU
1
;
Yan FENG
1
;
Min LI
1
;
Jianrong KOU
1
;
Junsong WEI
1
;
Weiyi FENG
1
Author Information
1. Dept. of Pharmacy，the First Affili ated Hospital of Xi’an Jiaotong University，Xi’an 710061，China
- Publication Type:Journal Article
- Keywords:
anti-tumor drug;
vinorelbine;
pharmacokinetics;
curative effect;
toxicity;
pharmacodynamic index
- From:
China Pharmacy
2022;33(11):1403-1408
- CountryChina
- Language:Chinese
-
Abstract:
Vinorelbine（NVB）is a semisynthetic vinca alkaloid and can play an anti-tumor role by inhibiting the synthesis of tubulin. Its oral preparation has been used in the treatment of a variety of tumors as its convenience and good clinical response. The blood concentration of NVB is closely related to its curative effect and toxicity. Small variations in blood concentration may reduce the curative effect and even produce serious toxicity. There are some risks in the clinical drug use due to limited clinical data and effective pharmacodynamic monitoring methods. By reviewing the relevant literature at home and abroad ，this paper summarizes the research progress of in vivo pharmacokinetics and toxicity of NVB ，fully understands the pharmacokinetic characteristics and influencing factors of NVB ，the influencing factors of toxicity ，and the application status of pharmacokinetics in the adjustment of administration scheme ，so as to provide reference for its clinical rational use.
