Effect of Electroacupuncture on Expression of Phosphodiesterase 4 and Subtypes in Hippocampus in Rats with Chronic Stress Depression
10.3969/j.issn.1006-9771.2016.09.005.
- VernacularTitle:电针对慢性应激抑郁模型大鼠海马磷酸二酯酶4及其亚型表达的影响①
- Author:
Quankai JING
1
;
Chaoketu SAIYIN
2
;
Haijiang YAO
3
,
4
,
5
;
Wei LV
1
;
Youdou AOCUN
1
;
Lijuan YANG
1
;
Juntong LIU
1
;
Zhigang LI
1
Author Information
1. 1. Department of Acupuncture and Massage, Beijing University of Chinese Medicine, Beijing 100029, China
2. 2. Inner Mongolia International Mongolian Hospital Traditional Therapy Technique, Hohhot, Inner Mongolia 010065, China
3. 3. Treatment Center of Traditional Chinese Medicine, Beijing Bo'
4. ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
5. 4. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
- Publication Type:Journal Article
- Keywords:
depression, electroacupuncture, chronic stress, phosphodiesterase 4, rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(9):1011-1014
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the biological mechanisms of electroacupuncture (EA) for depression. Methods Forty male adult Sprague-Dawley rats were randomly divided into control group (n=8), model group (n=8), EA group (n=8) and fluoxetine group (n=8). Depressive models were established with lonely raising and chronic unpredictable mild stress. They were tested with Open-field Test, and the expression of phosphodiesterase 4 (PDE4)A and PDE4D in hippocampus was detected with RT-PCR. Results The cross and rear scores were significantly lower in the model group than in the control group (P<0.001), while it increased in the EA group and the fluoxetine group (P<0.001). Compared with the model group, the expression of PDE4A and PDE4D decreased in the EA group (P<0.001). Conclusion Electroacupuncture may relieve depression through inhibiting the expression of PDE4A and PDE4D.
