Interaction between cyclosporine A and voriconazole in patients with allogeneic hematopoietic stem cell transplantation
10.12206/j.issn.1006-0111.202111056
- VernacularTitle:异基因造血干细胞移植患者体内环孢素A和伏立康唑的相互作用
- Author:
Yani WANG
1
,
2
,
3
;
Di WU
1
,
3
;
Zhi RAO
4
;
Maoxing LI
1
,
3
;
Rui XI
5
;
Jun REN
5
Author Information
1. Department of Clinical Pharmacy, No. 940 Hospital of Joint Logistics Support Force of the PLA, Lanzhou 730050, China
2. Department of Clinical Pharmacy, Traditional Chinese Medicine Hospital of Baoji, Baoji 721000, China
3. School of Pharmacy, Ningxia Medical College, Yinchuan 750001, China.
4. Department of Pharmacy, First Hospital of Lanzhou University, Lanzhou 730000, China.
5. Department of Clinical Pharmacy, No. 940 Hospital of Joint Logistics Support Force of the PLA, Lanzhou 730050, China.
- Keywords:
CsA;
VRZ;
blood concentration;
therapeutic drug monitoring;
drug interaction
- From:
Journal of Pharmaceutical Practice
2022;40(3):277-280
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the drug-drug interaction (DDI) between intravenous voriconazole (VRZ) and intravenous cyclosporine (CsA) in patients after allogeneic hematopoietic stem cell transplantation (Allo-HSCT) and provide an individualized and accurate clinical drug delivery. Methods In a self-contrast study, Allo-HSCT patients from January 2019 to December 2019 were enrolled according to the inclusion and exclusion criteria. These patients were treated with CsA and VRZ successively and the blood concentration of CsA and VRZ before and after 5-7 days of VRZ administration were determined with LC-MS/MS. The correlation between the concentration of VRZ and concentration/dose (C/D) ratio of CsA was analyzed with SPSS20.0. Results A total of 15 patients with ALLo-HSCT were enrolled. Wilcoxon sign rank sum test was used to compare the change of median C/D of CsA before and after VRZ administration, which had shown significant difference (P<0.001). Spearman correlation analysis was conducted on the increase of C/D ratio between VRZ and CsA, which had no significant correlation between them (ρ=−0.273, P=0.32). Conclusions There was obvious drug-drug interaction (DDI) between CsA and VRZ. VRZ increased CsA blood concentration significantly, but there was no significant correlation between VRZ blood concentration and the degree of concentration increase, which might be related to individual difference.
