Mechanism of Psoralea corylifolia Linn on liver injury based on bioinformatics
10.12206/j.issn.1006-0111.202103054
- VernacularTitle:基于生物信息学技术探讨补骨脂致肝损伤的作用机制
- Author:
Dan YU
1
;
Xiaowei CHI
2
Author Information
1. School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
2. Development Center for Medical Science & Technology National Health Commission of the People's Republic of China, Beijing 100044, China.
- Keywords:
Psoralea corylifolia Linn;
bioinformatics;
liver injury
- From:
Journal of Pharmaceutical Practice
2022;40(3):254-258
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of Psoralea corylifolia Linn (PCL) on liver injury by establishing the biological function and pathway network of PCL components, targets and protein interactions based on bioinformatics. Methods The components of PCL and potential liver-injury related targets were collected from TCMIP database. The targets of PCL were predicted by the reverse pharmacophore matching method. Cytoscape software was applied for the construction of active components-targets network map. Protein-protein interaction network was constructed by STRING database. Gene ontology functional enrichment analysis and KEGG pathway enrichment analysis were conducted to predict the liver injury mechanism of PCL. Results 22 components were identified from PCL with the corresponding 31 potential liver injury targets, mainly on serum albumin (ALB), glutathione S-transferase P (GSTP1), transthyretin (TTR) and peroxisome proliferator activated receptor gamma (PPARG) by PPI network analysis. The chemical carcinogenesis, adenosine 5 '- monophosphate activated protein kinase (AMPK) signal, PPAR signal, liver enzyme P450 and its harmful substance metabolism, glutathione metabolism and other signaling pathways were selected by KEGG analysis. Conclusion The active components of PCL may target on ALB, GSTP1, TTR and PPARG to regulate AMPK and PPAR signaling pathways, leading to liver injury.
