Advances in methodologies for preparation and analysis of new biochromatic stationary phase
10.12206/j.issn.1006-0111.202112087
- VernacularTitle:新型生物色谱固定相制备及分析方法学研究进展
- Author:
Xinyi CHAI
1
;
Yanqiu GU
2
;
Xiaofei CHEN
1
;
Yifeng CHAI
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
2. Department of Pharmacy, Ninth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 201999, China.
- Keywords:
biochromatography;
immobilization method;
drug screening;
monolithic column
- From:
Journal of Pharmaceutical Practice
2022;40(3):193-198
- CountryChina
- Language:Chinese
-
Abstract:
Biochromatography is a new chromatographic technology with great development potential. It has been widely used in drug screening and biomolecular interaction analysis. The core of this technology is the chromatographic stationary phase of biomolecules. Nowadays, it mainly develops cell membrane chromatography, artificial biomimetic membrane chromatography and the various immobilization strategies to directly immobilizes proteins on the stationary phase carrier. This paper reviews the research progress of new biochromatographic stationary phase and the application of biochromatographic analysis based on new stationary phase. And, the applications of biochromatographic stationary phase and micro biochromatographic analysis system based on monolithic column are prospected.
