Predictive value of low-density lipoprotein cholesterol in cardiovascular events in elderly diabetic patients
10.3969/j.issn.1006-2483.2022.03.035
- VernacularTitle:低密度脂蛋白胆固醇对老年糖尿病患者心血管事件的预测价值
- Author:
Tao HE
1
;
An DING
1
Author Information
1. Department of Cardiovascular Medicine, Hubei Jianghan Oilfield General Hospital, Qianjiang , Hubei 433124 , China
- Publication Type:Journal Article
- Keywords:
Senile diabetes;
Low density lipoprotein cholesterol;
Cardiovascular disease
- From:
Journal of Public Health and Preventive Medicine
2022;33(3):150-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the predictive value of low-density lipoprotein cholesterol (LDL-c) on cardiovascular events in elderly patients with diabetes, and to provide theoretical guidance for the prevention of cardiovascular disease in elderly patients with diabetes. Methods A total of 180 elderly patients with diabetes treated at the Department of Cardiovascular Medicine, Hubei Jianghan Oilfield General Hospital from June 2019 to June 2020 were selected. According to the LDL-c level, they were divided into low-risk group (LDL-c <2.6 mmol/L) and high-risk group (LDL-c ≥2.6 mmol/L). Ninety elderly people without diabetes who underwent physical examination during the same period were selected as the control group. During the physical examination, 5ml of fasting elbow venous blood was drawn from the elderly in the control group, and 5ml of fasting elbow venous blood was drawn from the patients in the experimental group upon admission. The age, gender, CRP, TC, TG, HDL-c, LDL-c levels and Gensini scores of all patients were determined. Spearman correlation analysis was used to analyze the correlation between LDL-c and blood lipid levels and Gensini scores of DM patients. All subjects were followed up for 1 year, and the incidence of MACE in all patients was analyzed. Spearman correlation analysis was used to analyze the correlation between LDL-c and the incidence of MACE in DM patients, and multivariate logistic regression was used to analyze the risk factors of MACE in DM patients. Results According to the serum LDL-c levels, 74 cases (41.11%) were in the high-risk group and 106 cases (58.89%) were in the low-risk group. There were no significant differences in age, gender, CRP and TC between the high-risk group and the low-risk group (P>0.05). The serum TG, TC, and LDL-c levels, and Gensini scores in the high-risk group were significantly higher than those in the low-risk group, and the serum LDL-c level in the high-risk group was significantly lower than that in the low-risk group (P<0.05). Serum LDL-c level of DM patients was positively correlated with TG and Gensini score (r=0.382,0.359, P<0.05), and negatively correlated with LDL-c (r=-0.378, P<0.05). Multiple linear regression analysis showed that LDL-c was independently correlated with Gensini score (P<0.05, corrected R2 =0.089). The incidence of MACE was 31.08% in the high-risk group and 14.15% in the low-risk group. The incidence of MACE in the high-risk group was significantly higher than that in the low-risk group (χ2=7.500, P<0.05). Spearman correlation analysis showed that LDL-C was positively correlated with the incidence of MACE (r=0.781, P<0.05). Multivariate logistic regression analysis showed that LDL-c≥2.6mmol/L was an independent risk factor for cardiovascular disease in elderly diabetic patients (P<0.05). The area under ROC curve for LDL-c to predict cardiovascular events in DM patients was 0.814 (95%CI:0.767~0.912), and the sensitivity and specificity were 78.40% and 84.80%, respectively. Conclusion LDL-c level is significantly increased in elderly patients with diabetes, and LDL-c≥2.6 mmol/L is of certain value in predicting cardiovascular events in patients with diabetes.
