The functions of Th17/Treg cells and relevant studies on the treatment of periodontitis and atherosclerosis
- Author:
ZHANG Yaoyue
1
;
LIN Xiaoping
1
Author Information
- Publication Type:Review
- Keywords: periodontitis; atherosclerosis; T helper cell 17; regulatory T cell; interleukin 17; cytotoxic T-lymphocyte-associated protein-4; periodontal intervention treatment
- From: Journal of Prevention and Treatment for Stomatological Diseases 2022;30(8):594-599
- CountryChina
- Language:Chinese
- Abstract: Periodontitis is a chronic infectious disease in which periodontal tissue loss is caused by dental plaque biofilm. Atherosclerosis is a chronic inflammatory disease that occurs in the walls of arteries and is characterized by lipid accumulation. Recently, many studies have suggested that there is a certain relationship between periodontitis and atherosclerosis. From an epidemiological perspective, a previous literature review indicated that patients with periodontitis have a higher incidence of atherosclerosis. IL-17 secreted by Th17 cells may aggravate the progression of the two diseases by elevating the levels of matrix metalloproteinases, which may damage the connective tissue. Treg cells reduce the activation of T cells and limit the development of inflammation by secreting anti-inflammatory factors and expressing coinhibitory molecules. Periodontal intervention may contribute to the treatment of atherosclerosis by reducing inflammatory markers in atherosclerosis. Many studies have shown that periodontitis and atherosclerosis may interact with each other, but further studies are needed to explore the concrete mechanism of the interaction between periodontitis and atherosclerosis.
- Full text:Th17_Treg细胞在牙周炎与动脉粥样硬化发病中的作用及牙周干预治疗的相关研究.pdf
