Clinical analysis of 8 cases of desmoplastic fibroma of the jaw
10.12016/j.issn.2096-1456.2022.08.006
- Author:
HU Mingjing
1
;
WANG Zhiyong
1
Author Information
1. Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University
- Publication Type:Journal Article
- Keywords:
desmoplastic fibroma of bone;
fibrogenic bone tumor;
ligamentoid fibroma of bone;
intraosseous desmoid fibroma;
intraosseous invasive fibroma;
maxilla;
mandible;
treatment;
curettage;
extended resection;
prognosis;
recurrence;
retrospective analysis
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2022;30(8):571-577
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To improve the dentist's understanding of desmoplastic fibroma of the jaw, we investigated the clinical manifestations, pathological features, treatment and prognosis of this disease.
Methods:The clinical data of 8 patients with desmoplastic fibroma of the jaw who were admitted to Nanjing Stomatological Hospital from 2011 to 2021 were retrospectively reviewed.
Results :The male-female ratio in this group was 3:1, the age of first onset was 32.13±15.00, and the lesions were mainly in the mandible. Histologically, the lesions was composed of mildly atypical fibroblasts and a large number of collagen fibers. The positive rates of Vimentin, α-SMA and β-catenin in the cytoplasm were 100%, 62.5% and 62.5%, respectively. The Ki-67 level in the initial patients was lower than 5%, and the S-100 protein level was 100% negative. The imaging manifestations were single-room or multichamber light-transmitting lesions with clear or irregular boundaries, with or without peripheral sclerosis. Five patients were treated with curettage for the first time; among them, two patients relapsed with poor prognosis. Three patients underwent extended resection, and all had no recurrence.
Conclusions : The clinical and imaging features of desmoplastic fibroma of the jaw are not specific. We mainly rely on histopathology to diagnose the disease. It has a high recurrence rate after surgery. At present, the best treatment is to extend surgical resection. Local curettage is easy to relapse and has a poor prognosis.
