Comparison of Clinical and Neuroimaging Features between Acute Ischemic Stroke Patients with and without Cancer
10.3969/j.issn.1006-9771.2018.11.016
- VernacularTitle:恶性肿瘤与非肿瘤患者发生脑梗死的临床与影像特点比较
- Author:
Linjia GUO
1
;
Feng YU
1
;
Jing CHEN
1
;
Yuhui YIN
1
;
Shu HOU
1
Author Information
1. Department of Neurology, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing 10038, China
- Publication Type:Journal Article
- Keywords:
ischemic stroke, cancer, clinical features
- From:
Chinese Journal of Rehabilitation Theory and Practice
2018;24(11):1338-1343
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the differences of clinical and neuroimaging features between ischemic stroke patients with and without cancer. Methods From January 2013 and July 2017, 41 patients with active cancer diagnosed as acute ischemic stroke were retrospectively analyzed as research group. Besides, 41 age-and sex-matched patients diagnosed as acute ischemic stroke without cancer were selected as control group. The clinical date of both groups were collected and analyzed statistically. Results The percentages of hypertension, hyperlipidemia and past stroke were lower (χ2 > 5.549, P < 0.05), and the percentage of patients with cryptogenic stroke was higher in the research group than in the control group (χ2 > 17.537, P < 0.05). The hemoglobin level was lower (t = 4.609, P < 0.001), the D-dimer level was higher (t = -5.796, P < 0.001) in the research group than in the control group. Multiple vascular lesions of 53.7% patients in the research group were higher than 4.9% in the control group. The percentage of DWI lesions involving three vessel territories was higher in the research group than in the control group (χ2 > 17.995, P < 0.01). The percentage of multiple small lesions, and lesions located in cortical/subcortical lesions or cerebellum was higher in the research group than in the control group (χ2 > 8.159, P < 0.01). The 30 days mRS score after ischemic stroke (t = -3.222, P < 0.01) and the mortality rate within 30 days (P < 0.05) were higher in the research group than in the control group. Conclusion Compared with ischemic stroke patients without cancer, there were more cryptogenic stroke, higher D-dimer levels and poor prognosis in patients with active cancer. In ischemic stroke, patients with active cancer has a unique focal distributions characterized by more multiple vascular lesions involving three vessel territories and more lesions located in cortical/subcortical and cerebellum. The patients with ischemic stroke who conform to above characteristic should be paied attention to tumor screening.
