Advance in Role of Neuropeptide Y Receptors System in Pain Modulation (review)

VernacularTitle:神经肽Y受体系统参与痛觉调制的研究进展
Author: Shuxuan ZHAO ^{1
,

2} ; Dongliang ZHANG ^{1
,

2} ; Wei SHEN ^{1
,

2} ; Xiaofei FENG ^{1
,

2} ; Zheng LIU ^{1
,

2} ; Wenhua YUAN ^{1
,

2} ; Haiyu ZHOU ¹
Author Information

1. 1. Department of Orthopedics, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China
2. 2. Key Laboratory of Bone and Joint Diseases of Gansu Province, Lanzhou, Gansu 730030, China
Publication Type:Journal Article
Keywords: neuropeptide Y, receptors, pain modulation, review
From: Chinese Journal of Rehabilitation Theory and Practice 2018;24(11):1284-1287
CountryChina
Language:Chinese
Abstract: The neuropeptide Y receptors system is a receptor-ligand system composed of neuropeptide Y and its receptors, which is represented by two subtypes, including Y1 receptor (Y1R) and Y2 receptor (Y2R). The system is widely involved in pain modulation in mammals. These receptors are G protein-coupled receptors, participating in neuronal membrane signaling. Neuropeptide Y receptors distribute in the pain-related regions of the central nervous system, play a variety of roles in maintains neuronal activity of pain transmission, relate to the specificity of distribution. At the spinal level, Y1R plays an analgesic role, whereas Y2R is usually related to pain-promoting. The system can also take part in cerebral pain modulation at different nuclei.