Advance of Rab27a Gene and Exosomes (review)

VernacularTitle:Rab27a基因与外泌体的研究进展
Author: Xiao WANG ^{1
,

2} ; Yuen CHEN ^{1
,

2} ; Xiaotang MA ^{1
,

2} ; Qunwen PAN ^{1
,

2} ; Zihui HUANG ^{1
,

2}
Author Information

1. 1. Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524002, China
2. 2. Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, China
Publication Type:Journal Article
Keywords: Rab27a gene, exosomes, inflammation, tumor, review
From: Chinese Journal of Rehabilitation Theory and Practice 2018;24(10):1159-1164
CountryChina
Language:Chinese
Abstract: Rab27a gene can participate in the secretion, transportation and exocytosis of T lymphocytes, mast cells, neutrophils, pancreatic β cells and hematopoietic cells through its encoded proteins, and participate in the development of diseases such as albinism, cancer, diabetes, inflammation and thrombosis. In addition, the secretion regulation of Rab27a to exosomes has also received much attention. The current research status of the secretion of exosome and the genetically modified exosomes of Rab27a gene in the treatment of diseases such as inflammatory injury, thrombosis and tumor were reviewed.