Relationship between Val158Met Polymorphism in Catechol-O-methyltransferase Gene and Depression in Parkinson's Disease
10.3969/j.issn.1006-9771.2018.07.001
- VernacularTitle:儿茶酚胺氧位甲基转移酶基因Val158Met多态性与帕金森病抑郁的相关性
- Author:
Huizi MA
1
;
Lingyan MA
1
;
Tao FENG
2
,
3
,
4
,
5
Author Information
1. Center for Neurodegenerative Disease, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
2. 1. Center for Neurodegenerative Disease, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
3. 2. China National Clinical Research Center for Neurological Disease, Beijing 100050, China
4. 3. Parkinson'
5. s Disease Center, Beijing Institute for Brain Disorder, Capital Medical University, Beijing 100050, China
- Publication Type:Journal Article
- Keywords:
Parkinson's disease, depression, catechol-O-methyltransferase, Val158Met, polymorphism
- From:
Chinese Journal of Rehabilitation Theory and Practice
2018;24(7):753-756
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the polymorphism of catechol-O-methyltransferase (COMT) gene Val158Met site and depression in Parkinson's disease. Methods From June, 2016 to December, 2017, a cohort of 268 Chinese patients with Parkinson's disease and 252 age- and gender-matched healthy control subjects were recruited. The patients were divided into depression group (n=116) and non-depression group (n=152) according to Hamilton Depression Scale score. Their blood samples were collected and the polymorphism of Val158Met was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results No difference was identified in Val158Met polymorphism of genotype (χ2=0.78, P>0.05) and allele (χ2=0.25, P>0.05) among the depression group, the non-depression group and the control group. Conclusion The polymorphism of Val158Met in COMT gene does not contribute to the risk of depression in Parkinson's disease in China.
