Role of p 38 MAPK signaling pathway on post-stroke cognitive impairment and pharmacological research progress in the prevention and treatment with traditional Chinese medicine
- VernacularTitle:p38MAPK信号通路在脑卒中后认知障碍中的作用及在中药防治中的药理研究进展
- Author:
Zhimin DING
1
;
Jing GAO
1
,
2
;
Kaiqi SU
1
,
2
;
Mingyue YU
1
;
Shikui QI
1
;
Yixuan FENG
1
;
Xiaodong FENG
1
Author Information
1. School of Rehabilitation Medicine，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Rehabilitation Centre，the First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450099，China
- Publication Type:Journal Article
- Keywords:
post-stroke cognitive impairment;
traditional Chinese medicine;
p38 mitogen-activated protein kinase signaling
- From:
China Pharmacy
2022;33(8):1014-1020
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke cognitive impairment （PSCI） refers to a series of syndromes from mild cognitive impairment to dementia caused by stroke. The mitogen-activated protein kinases （MAPK）signaling pathway is a key pathway for transmitting cellular signals in mammals ，and p 38 is a classic branch of it. p 38 MAPK signaling pathway is involved in various pathophysiological processes such as cell growth ，differentiation，apoptosis and inflammatory response in central nervous system diseases. At present ，great progress has been made in clinical and basic experimental studies on prevention and treatment of PSCI by traditional Chinese medicine （TCM），but there is a lack of relevant systematic summary. Therefore ，this article summarizes the role of p 38 MAPK signaling pathway in PSCI and the pharmacological research progress of TCM in prevention and treatment of PSCI through p 38 MAPK signaling pathway.
