Incidence and risk factors analysis of colorectal adenomatous polyps in recipients after liver transplantation
10.3969/j.issn.1674-7445.2022.03.017
- VernacularTitle:肝移植受者术后结直肠腺瘤性息肉发生情况及危险因素分析
- Author:
Xiaoqing JIANG
1
;
Wei RAO
;
Peng ZHANG
;
Yingjun JIANG
;
Xinjuan KONG
;
Man XIE
Author Information
1. Department of Gastroenterology, Weifang Yidu Central Hospital, Weifang 262500, China
- Publication Type:Research Article
- Keywords:
Liver transplantation;
Colorectal adenomatous polyps;
Inflammatory polyps;
Colorectal cancer;
Intraepithelial neoplasia;
Ciclosporine;
Sirolimus;
Tacrolimus
- From:
Organ Transplantation
2022;13(3):393-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the incidence and risk factors of colorectal adenomatous polyps (CAP) in recipients after liver transplantation. Methods Seventy-seven liver transplant recipients and 231 individuals undergoing colonoscopy during physical examination were recruited in this study. The incidence of CAP and pathological examination results were analyzed. Clinical data of liver transplant recipients were collected. According to the incidence of CAP, liver transplant recipients were divided into the CAP group (n=28) and non-CAP group (n=49). The risk factors of CAP after liver transplantation were identified. Results The 5-year cumulative incidence rates of colorectal polyps in liver transplant recipients and physical examination individuals were 43% and 34%, and 29% and 23% for the 5-year cumulative incidence rates of CAP, with no significant differences (both P > 0.05). Among all liver transplant recipients, 65 polyps were detected. The quantity of polyps in 1 case was excessively high and not counted. Multiple polyps were identified in certain recipients. Five polyps were not prepared for pathological examination due to small size. Pathological examination of 60 polyps demonstrated 25 inflammatory polyps, 33 CAP (8 complicated with low-grade intraepithelial neoplasia and 3 complicated with high-grade intraepithelial neoplasia), and 2 well-differentiated adenocarcinoma. Cox model analysis prompted that use of ciclosporine after liver transplantation was an independent risk factor for CAP in the recipients. Conclusions The risk of CAP is slightly elevated after liver transplantation. Postoperative use of ciclosporine is an independent risk factor for CAP in recipients after liver transplantation. Colonoscopy should be emphasized in the recipients after liver transplantation.
