Research progress of NF-κB signaling pathway in kidney ischemia-reperfusion injury
10.3969/j.issn.1674-7445.2022.03.011
- VernacularTitle:NF-κB相关信号通路在肾缺血-再灌注损伤中作用的研究进展
- Author:
Ruibo ZHANG
1
;
Kaiwen SHEN
;
Qiang YUAN
;
Qiang WANG
;
Jun SHEN
Author Information
1. Guizhou Medical University, Guiyang 550004, China
- Publication Type:Research Article
- Keywords:
Kidney transplantation;
Nuclear factor-κB;
Inflammation;
Ischemia-reperfusion injury;
Poly adenosine-diphosphate-ribose polymerase -1;
Toll-like receptor 4;
NOD-like receptor protein 3;
Hypoxia inducible factor-1α
- From:
Organ Transplantation
2022;13(3):349-
- CountryChina
- Language:Chinese
-
Abstract:
Kidney ischemia-reperfusion injury (IRI) is the major cause of poor prognosis after kidney transplantation and partial nephrectomy. Besides, it is also a critical pathophysiological process of acute kidney injury. Consequently, the prevention and treatment of kidney IRI are of significance to improve clinical prognosis of recipients undergoing kidney transplantation. However, the mechanism underlying IRI is complex, and the exact mechanism remains elusive. Inflammation, as one of the main pathogenesis of IRI, plays a significant role in IRI-induced kidney injury. Nuclear factor (NF)-κB, as a rapid response transcription factor, has been proven to be involved in the regulation of inflammation during kidney IRI. Therefore, in this article, the structure of NF-κB, the activation pattern of NF-κB signaling pathway, the regulatory mechanisms of NF-κB upstream and downstream signaling pathways in kidney IRI were reviewed, and the role of NF-κB signaling pathway in kidney IRI was investigated, aiming to provide novel clinical ideas for the prevention and treatment of kidney IRI.
