Research progress on basic immunology of organ transplantation in 2021
10.3969/j.issn.1674-7445.2022.03.006
- VernacularTitle:2021年器官移植基础免疫学研究进展
- Author:
Changhong WU
1
;
Ya'nan XU
;
Qianchuan TIAN
;
Yong ZHAO
Author Information
1. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
- Publication Type:Research Article
- Keywords:
Organ transplantation;
Transplantation immunology;
Rejection;
Immune tolerance;
Regional immune response;
Tissue-resident immune cell;
Immunosuppression;
Molecular material;
Therapeutic drug monitoring
- From:
Organ Transplantation
2022;13(3):317-
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the science and technology of organ transplantation have developed rapidly, which has been widely applied worldwide. However, multiple challenges remain to be resolved by clinicians, such as functional damage and immune rejection of transplant organs, immune deficiency caused by extensive use of immunosuppressants, chronic allograft dysfunction and adverse reactions. This article introduced relevant key research results published in 2021, taking the function and mechanism of immune cell subsets in the process of organ transplantation rejection or immune tolerance, and the research and application of new materials and drugs in organ transplantation as the main clues. The latest research progresses on regional immune response, especially the application of tissue-resident memory T cell in organ transplantation, were briefly summarized, and the future development of transplantation immunology was prospected.
