Immunosuppressive management in pediatric kidney transplant recipients
10.3969/j.issn.1674-7445.2022.03.001
- VernacularTitle:儿童肾移植受者的免疫抑制管理
- Author:
Wenyu ZHAO
1
;
Youhua ZHU
Author Information
1. Department of Organ Transplantation, the First Affiliated Hospital, Naval Medical University, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
Pediatric kidney transplantation;
immunosuppresant;
Immune induction;
Immune maintenance;
Immune monitoring;
Glucocorticoid withdrawal;
Medication compliance;
Pharmacokinetics
- From:
Organ Transplantation
2022;13(3):283-
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, clinical efficacy of pediatric kidney transplantation has been gradually enhanced with persistent progress of organ allocation policy, surgical technologies and perioperative management, etc. However, immunosuppressive management still plays a significant role in the long-term prognosis of pediatric kidney transplant recipients. Due to the disparity from adults in physiology, psychology, immune system and drug metabolism, immunosuppressive management in children should be delivered in a specific manner. Therefore, it is necessary to select appropriate immunosuppresants and formulate individualized immunosuppressive regimens according to the characteristics of pediatric kidney transplant recipients in clinical practice. In this article, the characteristics of immunosuppressive therapy, selection of immunosuppresants, glucocorticoid withdrawal, immune monitoring and medication compliance management of pediatric kidney transplant recipients were investigated, aiming to provide reference for optimizing immunosuppressive management and improving clinical prognosis of pediatric kidney transplant recipients.
