Effect of Mirabegron combined with Silodosin on detrusor hyperactivity with impaired contractile
10.3969/j.issn.1006-9771.2022.04.015
- VernacularTitle:米拉贝隆联合赛洛多辛治疗逼尿肌过度活动伴收缩功能受损患者的效果
- Author:
Huiling CONG
1
,
2
;
Limin LIAO
1
,
2
;
Guang FU
1
,
2
;
Lihua ZHA
1
,
2
;
Yuqi YANG
2
,
3
;
Yizheng WANG
2
,
4
,
5
,
5
;
Xing LI
1
,
2
;
Juan WU
2
,
6
;
Yi GAO
2
,
6
;
Huafang JING
2
,
6
Author Information
1. a.Department of Urology , Beijing Bo'
2. ai Hospital, China Rehabilitation Research Center, Beijing 100068, China 2. Capital Medical University School of Rebabilitation Medicine, Beijing 100068, China
3. b.Department of Neurological Rehabilitation, Beijing Bo'
4. c.Department of VIP Rehabilitation, Beijing Bo'
5. ai Hospital, China Rehabilitation Research Center, Beijing 100068, China 2. Capital Medical University School of Rebabilitation Medicine, Beijing 100068, China, Beijing Bo'
6. d.Department of Neurourological Ward, Beijing Bo'
- Publication Type:Journal Article
- Keywords:
Mirabellone, Silodosin, detrusor overactivity with impaired contractile function, drug combination, urinary rehabilitation
- From:
Chinese Journal of Rehabilitation Theory and Practice
2022;28(4):473-478
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of Mirabegron combined with Silodosin on detrusor hyperactivity with impaired contractile (DHIC).Methods From September, 2019 to December, 2021, 40 patients with DHIC in the Department of Urology of Beijing Bo'ai Hospital were selected and randomly divided into control group and experimental group, with 20 cases in each group. The control group took Silodosin only, and the experimental group took Mirabegron in addition, for four weeks. The urinary diary, residual urine volume, Overactive Bladder Symptom Score (OABSS) and quality of life (QOL) score were compared before and after treatment.Results A total of 18 patients in the control group and 19 in the experimental group finished the trial. After treatment, the number of night urination per day, the residual urine volume and QOL score improved in the control group (P<0.01); the number of urination per 24 hours, the number of night urination per day, the volume per urination, the residual urine volume, the daily urgency score, the OABSS score and QOL score improved in the experimental group (P<0.01). The number decrease of urination per 24 hours, the volume decrease of per urination, the daily urgency score decrease, the OABSS score decrease and QOL score decrease were more in the experimental group than in the control group (P<0.01). The adverse reactions included palpitations, increased heart rate, dyspareunia, increased blood pressure, gastric discomfort, postural hypotension, and retrograde ejaculation, and there was no significant difference between two groups (P > 0.05).Conclusion The efficacy of Mirabellone combined with Silodosin on DHIC is better than Silodosin only, and there was no significant increase in drug-related adverse effects.
