Effects of enteral nutrition beginning at different time on aspiration rate and immune function in patients with severe traumatic brain injury
10.3969/j.issn.1006-9771.2022.04.013
- VernacularTitle:肠内营养启动时间对重型脑外伤患者误吸率和免疫功能的影响
- Author:
Yan CHEN
1
,
2
;
Yongxiang WANG
3
,
4
;
Yijuan GU
2
;
Xiaoqin LIU
2
;
Qianqian ZHUANG
5
,
6
,
7
;
Xiaoli MENG
2
;
Xiaozhu SHEN
7
,
8
Author Information
1. 1. School of Nursing, Yangzhou University, Yangzhou, Jiangsu 225000, China
2. a.Department of Neurosurgery , Lianyungang, Jiangsu 222000, China
3. 3. Northern Jiangsu People'
4. s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225000, China
5. 2. a.Department of Neurosurgery
6. b.Department of Geriatrics, the Second People'
7. s Hospital of Lianyungang, Lianyungang, Jiangsu 222000, China
8. b.Department of Geriatrics, the Second People'
- Publication Type:Journal Article
- Keywords:
severe traumatic brain injury, early enteral feeding, aspiration, immune function
- From:
Chinese Journal of Rehabilitation Theory and Practice
2022;28(4):461-466
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of enteral nutritional support beginning at different time on aspiration events and immune function in the early post-traumatic (within 14 days) period in patients with severe traumatic brain injury.Methods From June, 2018, to February, 2021, 75 patients with acute traumatic brain injury admitted in the Department of Neurosurgery of the Second People's Hospital of Lianyungang were randomly divided into early feeding group (24 to 48 hours, n=35) and delayed feeding group (48 to 120 hours, n=40). The 14-day reflux rate, aspiration rate, incidence of aspiration pneumonia, immune indexes and complications were compared between two groups.Results There was no significant difference in the reflux rate, aspiration rate and the incidence of aspiration pneumonia between the two groups (P > 0.05). The levels of IgG, IgA, and complements C3 and C4 were significantly higher in the early feeding group than in the delayed feeding group (|t| > 1.720, P<0.001). The incidence of non-aspiratory lung infections was significantly lower in the early feeding group than in the delayed feeding group (χ2=4.728, P<0.05).Conclusion Initiating enteral nutrition within 24 to 48 hours after injury may preserve immune function and reduce the incidence of non-aspiratory lung infections in patients with severe traumatic brain injury.
