Progress of cellular growth factors in neurorehabilitation and neuroplasticity
10.3969/j.issn.1006-9771.2021.00.005
- VernacularTitle:细胞生长因子在神经康复与神经可塑性中的研究进展
- Author:
Xiaokun LI
1
;
Xu LIU
2
;
Jiahua LIU
3
;
Zhiheng RAO
1
;
Yingde LUO
1
;
Keyang CHEN
1
;
Tong ZHANG
4
,
5
Author Information
1. 1. International Growth Factor Research Institute, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
2. 2. Department of Rehabilitation, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
3. a. Department of Physical Therapy, Rehabilitation Research Center, Beijing 100068, China
4. b.Department of Neurology, Beijing Bo'
5. ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
- Publication Type:Journal Article
- Keywords:
cellular growth factors, neurorehabilitation, neuroplasticity, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2022;28(2):175-182
- CountryChina
- Language:Chinese
-
Abstract:
With potent biological activities, cellular growth factors are polypeptide factors that primarily stimulate cell growth and proliferation. They participate in the regulation of not only normal physiological functions such as human embryonic development and cell growth, but also neurorehabilitation and neuroplasticity in pathological processes such as nerve injury and recovery. Specifically, cellular growth factors have been shown to promote neuron survival, facilitate nerve regeneration and regulate synaptic plasticity, promote cell differentiation/vascular regeneration and modulate the microenvironment, promote nerve fiber myelination and improve nerve conduction. This review summarized current knowledge on the roles and various growth factors in neurorehabilitation and neuroplasticity, providing an update on potential clinical application of cellular growth factors in the field of neural rehabilitation.
