Preparation and in vivo evaluation of a novel allicin pro-drug tablet
10.11665/j.issn.1000-5048.20220210
- VernacularTitle:大蒜辣素前体微丸片的制备及其体内评价
- Author:
Juan TAO
1
;
Yanhui SU
;
Yuan ZHOU
;
Chunli ZHENG
Author Information
1. 江苏护理职业学院药学与中药学院
- Publication Type:Journal Article
- Keywords:
allicin;
pro-drug;
alliin;
alliinase;
antacid pellet;
hyperlipidemia
- From:
Journal of China Pharmaceutical University
2022;53(2):200-206
- CountryChina
- Language:Chinese
-
Abstract:
A novel allicin pro-drug tablet containing antacid pellets was developed to realize pH-regulated allicin release and to guarantee allicin yield in stomach environment.Firstly, allicin precursor pellets containing antacid pellet were prepared and artificial gastric juice was used as the medium to determine the yield of the allicin.Then, the total lipid cholesterol (TC), triglyceride cholesterol (TG), high density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) were used as indicators to study the hypolipidemic effect of allicin precursor pellets in rats.The dissolution test showed that in artificial gastric juice, the yield of allicin-containing antacid pellets exceeded 90%.In pharmacodynamic studies, it was found that antacid pellets showed the expected hypolipidemic effect on hyperlipidemia rats compared without antacid pellets.There was a very significant difference in blood lipid levels between the two test groups (P < 0.05).The allicin pro-drug tablets containing antacid pellets can effectively lower blood lipids.
