Synthesis and protective effect of carboxymethylcysteine L-arginate in bronchial epithelial cells
10.11665/j.issn.1000-5048.20220206
- VernacularTitle:羧甲司坦L-精氨酸盐的合成及其对支气管上皮细胞的保护作用
- Author:
Jian JIA
1
;
Jianbing WU
;
Yihua ZHANG
;
Zhangjian HUANG
Author Information
1. 中国药科大学新药研究中心
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
carboxymethylcysteine;
nitric oxide;
L-arginine;
reactive oxygen species;
apoptosis
- From:
Journal of China Pharmaceutical University
2022;53(2):171-177
- CountryChina
- Language:Chinese
-
Abstract:
Carboxymethylcysteine (CMC) is a common drug for the clinical treatment of chronic obstructive pulmonary disease, yet its long-term use can cause severe irritation to the gastrointestinal tract.As the substrate of nitric oxide (NO) synthase (NOS), L-arginine can be converted in the body into NO beneficial to the cardiovascular system, the gastrointestinal tract and so on.As a basic amino acid, L-arginine can be salified with some compounds containing acidic groups to improve the water solubility of the parent drug and may enhance the activity and alleviate side effects due to NO release.In this study, we designed and synthesized carboxymethylcysteine L-arginate (CMCA), and tested its physico-chemical properties, and the abilities to scavenge reactive oxygen species (ROS), inhibit apoptosis and release NO in cigarette smoke-induced injury model of human bronchial epithelial cells.The results revealed that CMCA is superior to CMC or L-arginine in that it could capture ROS, release NO and suppress apoptosis, suggesting that CMCA is worthy of further research and development.
