Advances in research on visualization of living cell drugs in vivo
10.11665/j.issn.1000-5048.20220204
- VernacularTitle:活细胞药物体内可视化研究进展
- Author:
Naijie WEI
1
;
Guangji WANG
;
Jingwei ZHANG
Author Information
1. 中国药科大学江苏省药物代谢动力学重点实验室
- Publication Type:Journal Article
- Keywords:
living cell drug;
in vivo imaging;
CAR-T cell;
mesenchymal stem cells;
advances
- From:
Journal of China Pharmaceutical University
2022;53(2):156-163
- CountryChina
- Language:Chinese
-
Abstract:
The development of living cell drugs and their successful application in clinical treatments require full clarification of the fate of cells after transplantation, which is critical to the safety and efficacy of living cell drugs.In order to solve this problem, cell imaging technology has come into our sight, and the use of visualization technology for non-invasive tracing of living cell drugs could reveal the distribution, homing and activity of living cell drugs in the body, which helps to determine the best number of transplanted cells, optimize the administration scheme, improve the transplantation efficiency, enhance the targeting of transplanted cells, and reduce the potential off-target accumulation risk.This paper summarizes the research advances of non-invasive visual tracing in vivo for living cell drugs from the perspectives of radionuclide imaging, magnetic resonance imaging, magnetic particle imaging, computed tomography imaging, fluorescence imaging and multimodal imaging.The aim is to obtain the biological behavior of living cell drugs in vivo with the application of appropriate contrast agent and tracing technology, and provide a more reasonable scientific basis for the research and development of living cell drugs and their transplantation therapy.
