Research progress of solute carriers in mediating nanomedicine across the blood-brain barrier
10.11665/j.issn.1000-5048.20220203
- VernacularTitle:溶质载体介导纳米药物载体跨越血脑屏障的研究进展
- Author:
Zhen LI
1
;
Yanyan LIU
;
Yan ZHAO
;
Yan SHEN
Author Information
1. 中国药科大学药学院药剂系
- Publication Type:Journal Article
- Keywords:
drug delivery;
blood-brain barrier;
solute carrier;
carrier-mediated transportation;
advances
- From:
Journal of China Pharmaceutical University
2022;53(2):146-155
- CountryChina
- Language:Chinese
-
Abstract:
As a structural barrier between the brain and the systemic circulation, the blood-brain barrier prevents macromolecules and most small-molecule drugs from entering the brain, which make it difficuct to treat central diseases.Various solute carriers such as glucose transporters and amino acid transporters which can transport various nutrients into the brain, are highly expressed on the blood-brain barrier.The ligand corresponding to the transporter is modified on the nano-drug carrier, and the drug is carried across the blood-brain barrier through transporter-mediated transport, which can achieve high-efficiency delivery of drugs to the brain and improve the diagnostic sensitivity and therapeutic effect of central diseases.In this paper, we review different types of solute carriers to mediate nanoformulations such as liposomes, metal nanoparticles, polymer micelles and dendrimers across the blood-brain barrier for the treatment of brain diseases and discuss the opportunities and challenges of this strategy in future applications.
