Advances in the synthetic methods of bicyclo[1.1.1]pentane derivatives
10.11665/j.issn.1000-5048.20220202
- VernacularTitle:双环[1.1.1]戊烷衍生物的合成研究进展
- Author:
Yu HUANG
1
;
Yinsheng ZHANG
Author Information
1. 正大天晴药业集团股份有限公司
- Publication Type:Journal Article
- Keywords:
bcyclo [1.1.1] pentane (BCP);
synthetic methods;
advances
- From:
Journal of China Pharmaceutical University
2022;53(2):137-145
- CountryChina
- Language:Chinese
-
Abstract:
Bicyclo [1.1.1] pentane (BCP) is a kind of bridged ring skeleton with a three-dimensional structure. As a bioisostere of benzene ring, tert-butyl and alkyne, it has been widely used in the field of medicinal chemistry.With the expansion of its application, the synthesis of BCP and its derivatives has become an increasingly attractive research hotspot for scientists.Based on this, the present article summarizes the main synthetic strategies and methods of BCP derivatives, in the hope of providing some reference for drug discovery researchers and some insight for new synthetic methods of such compounds.
