Effect of electroacupuncture on regional homogeneity of brain function in rats with vascular cognitive impairment
10.3969/j.issn.1006-9771.2022.01.009
- VernacularTitle:电针对血管性认知障碍大鼠脑功能局部一致性的效果
- Author:
Yanyi DING
1
;
Shenghang ZHANG
2
;
Yulu LIU
1
;
Yan YU
1
;
Minguang YANG
2
;
Shengxiang LIANG
2
;
Weilin LIU
2
;
Jing TAO
1
Author Information
1. 1. College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China
2. 2. The Academy of Rehabilitation Industry, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China
- Publication Type:Journal Article
- Keywords:
vascular cognitive impairment, electroacupuncture, working memory, regional homogeneity
- From:
Chinese Journal of Rehabilitation Theory and Practice
2022;28(1):55-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of electroacupuncture at Baihui (DU20) and Shenting (DU24) on brain functional activity and working memory of rats with vascular cognitive impairment (VCI). Methods Eighteen Sprague-Dawley rats were included, in which twelve rats were ligated bilateral common carotid arteries and six rats were not ligated (sham group). The modeled rats were randomly divided into model group (n = 6) and electroacupuncture group (n = 6). The electroacupuncture group received electroacupuncture at Baihui and Shenting for four weeks. They were assessed with Y maze and Morris water maze before and after intervention, and scaned with resting-state functional magnetic resonance imaging after intervention to calculate regional homogeneity (ReHo). Results Compared with the sham group, alternation rate of Y maze decreased (P < 0.001), and escape latency of Morris water maze increased (P < 0.05) in the model group and the electroacupuncture group before intervention. Compared with the model group, alternation rate of Y maze increased (P < 0.05), and escape latency of Morris water maze decreased (P < 0.05) after intervention in the electroacupuncture group. Compared with the sham group, ReHo of bilateral hippocampus, olfactory cortex, sensory cortex and auditory cortex, and left striatum decreased in the model group; compared with the model group, ReHo of bilateral prefrontal lobe, hippocampus and olfactory cortex, and left amygdala increased in the electroacupuncture group. Conclusion Electroacupuncture at Baihui and Shenting can improve the memory function of VCI rats, which may be related to the functional activities of prefrontal lobes, hippocampus and amygdala.
