Real-world research perspective: Evaluation of early follow-up outcomes in patients with partial and transitional atrioventricular septal defects
- VernacularTitle:真实世界研究角度：部分型和过渡型房室间隔缺损患者早期随访结果分析
- Author:
Zeyang YAO
1
,
2
,
3
;
Wen XIE
1
,
2
,
3
;
Zewen CHEN
3
,
4
;
Xiaodong ZENG
3
,
4
;
Xiaowei XU
3
,
4
;
Shusheng WEN
3
,
4
;
Tao LIU
5
,
6
,
7
;
Gang XU
3
,
4
;
Jian ZHUANG
1
,
2
,
3
Author Information
1. 1. School of Medicine, South China University of Technology, Guangzhou, 510080, P. R. China
2. 2.Department of Cardiovascular Surgery, Guangdong Provincial People'
3. s Hospital, Guangdong Academy of Medical Sciences, Guangdong Institute of Cardiovascular Disease, Guangzhou, 510080, P. R. China
4. Department of Cardiovascular Surgery, Guangdong Provincial People'
5. Department of Biostatistics, Center for Statistical Sciences, School of Public Health, Brown University,
6. East Providence, 02912,
7. USA
- Publication Type:Journal Article
- Keywords:
Partial;
transitional;
atrioventricular septal defect;
real-world study
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2022;29(04):457-462
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical characteristics of patients with partial and transitional atrioventricular septal defects (P/TAVSDs) in our hospital, and to evaluate the early follow-up outcomes from a real-world research perspective. Methods The clinical data of all patients diagnosed with P/TAVSDs from January 1, 2018 to July 12, 2020, in our hospital were collected, and all patients' examination results were used as the real-world follow-up data, univariable Cox risk proportional model was used to analyze the outcomes. A total of 93 patients were finally included in the analysis, 72 with partial and 21 with transitional AVSD. There were 38 males and 55 females at age of 182.0 months (20.0 d to 779.5 months). Results Univariable Cox proportional risk model suggested that at least one cardiac malformation (HR=15.00, 95%CI 3.00 to 75.00, P=0.001), preoperative moderate or greater mitral regurgitation (HR=6.60, 95%CI 1.70 to 26.00, P=0.007), and preoperative moderate or greater tricuspid regurgitation (HR=13.00, 95%CI 3.10 to 51.00, P<0.000 1) were risk factors for moderate or greater postoperative atrioventricular valve regurgitation. Conclusion Children with coarctation of the aorta or partial pulmonary vein connection, moderate or greater preoperative mitral regurgitation, and moderate or greater preoperative tricuspid regurgitation need to be alerted to the risk of moderate or greater postoperative atrioventricular valve regurgitation. Real-world data, with relaxed statistical P values and combined expertise, can suggest clinical conclusions that are close to those of high-quality retrospective studies.
