Perioperative nebulization of ipratropium bromide in patients with chronic obstructive pulmonary disease under thoracic surgery: A randomized, double-blind, placebo-controlled, parallel-group, multi-centre trial
- VernacularTitle:围手术期雾化吸入异丙托溴铵治疗胸外科手术合并COPD患者的随机、双盲、安慰剂对照、平行、多中心研究
- Author:
Lunxu LIU
1
;
Tianyou WANG
2
;
Xun ZHANG
3
;
Xiangning FU
4
,
5
;
Heng ZHAO
6
;
Zhijun LI
7
;
Yusheng YAN
8
;
Feng FAN
9
Author Information
1. Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China
2. Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, P. R. China
3. Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin, 300051, P. R. China
4. Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science &
5. Technology, Wuhan, 430032, P. R. China
6. Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China
7. Department of Thoracic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310036, P. R. China
8. Department of Thoracic Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, 510280, P. R. China
9. Department of Medicine, Boehringer Ingelheim (China) Investment Co. Ltd., Shanghai, 200040, P. R. China
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease (COPD);
perioperative period;
ipratropium bromide;
preoperative lung function;
postoperative pulmonary complications
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2022;29(04):417-423
- CountryChina
- Language:English
-
Abstract:
Objective To evaluate the effect of perioperative nebulization of ipratropium bromide on preoperative pulmonary function and incidence of postoperative pulmonary complications as well as safety in chronic obstructive pulmonary disease (COPD) patients who underwent lung resection in thoracic surgery. Methods During November 18, 2013 to August 12, 2015, 192 COPD patients with a necessity of selective surgical procedures of lobectomy or right bilobectomy or segmentectomy under general anaesthesia in 10 centers were 1 : 1 randomized to an ipratropium bromide group (96 patients) and a placebo group (96 patients), to compare the effect on preoperative pulmonary function and incidence of postoperative pulmonary complications. The average age of treated patients was 62.90±6.50 years, with 168 male patients and 22 female patients. Results The demographic and baseline characteristics were well-balanced between the two groups. The adjusted mean increase of forced expiratory volume in one second (FEV1) in the ipratropium bromide group was significantly higher than that in the placebo group (169.90±29.07 mL vs. 15.00±29.35 mL, P<0.05). The perioperative use of ipratropium bromide significantly decreased incidence of postoperative pneumonia (2.6% vs. 14.1%, P<0.05). There was no ipratropium bromide related adverse event (AE) observed in this trial. Conclusion This trial indicates that perioperative nebulization of ipratropium bromide significantly improves preoperative lung function and reduces postoperative pneumonia in COPD patients undergoing lung resection in thoracic surgery, and has good safety profile.
