In vitro hydrodynamic performance testing of heart valve prosthesis and its clinical application
- VernacularTitle:结构性心脏病时代医工结合：人工心脏瓣膜体外血流动力学性能测试及其临床意义
- Author:
Hao WANG
1
,
2
;
Da ZHU
3
;
Xiangyu BAO
4
;
Zhaoming HE
5
;
Li LIU
6
;
Xiangbin PAN
7
,
8
Author Information
1. Research Center of Fluid Machinery Engineering &
2. Technology, Jiangsu University, Zhenjiang, 212013, Jiangsu, P. R. China
3. Structural Heart Center, Fuwai Yunnan Cardiovascular Hospital, Kunming, 650000, P. R. China
4. Shanghai Heartpartner Testing Equipment Co., Ltd, Shanghai, 200000, P. R. China
5. Department of Mechanical Engineering, Texas Tech University, Lubbock, TX 79409, The United States of America
6. National Institutes for Food and Drug Control, Beijing, 102629, P. R. China
7. 2. Structural Heart Center, Fuwai Yunnan Cardiovascular Hospital, Kunming, 650000, P. R. China
8. 6. Structural Heart Center, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, 100037, P. R. China
- Publication Type:Journal Article
- Keywords:
Heart valve prosthesis;
in vitro testing;
hydrodynamic performance;
ISO 5840 international standard
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2022;29(03):279-287
- CountryChina
- Language:Chinese
-
Abstract:
The heart valve prosthesis must have excellent hydrodynamic performance which is usually tested in vitro, not in vivo. This paper comprehensively introduced the principles and methods of hydrodynamic performance in vitro testing, helping clinicians to understand valve performance parameters, evaluate valve applicability, and reduce clinical risk of the valve prosthesis. In vitro testing not only serves as the "gold standard" for valve prosthesis assessment, but also provides detailed data for design and optimization of the prosthesis. ISO 5840 defines the items and methods for valve in vitro testing, which consists of three parts: (1) pulsatile flow testing, which reproduces the pulsating flow of the valve prosthesis after implantation in the human body; (2) steady flow testing, which assesses valve forward flow resistance; (3) durability testing, which evaluates the durability of the valve prosthesis and determines the expected failure mode. In addition, the paper presented the differences between atrioventricular and aortic valve testing, the method of mitral valve testing, the differences between transcatheter and surgical valve testing, and the method of valve flow visualization.
