Mechanism of action of ferroptosis in cholangiocarcinoma
10.3969/j.issn.1001-5256.2022.04.043
- VernacularTitle:铁死亡在胆管癌中的作用机制
- Author:
Mingyu YANG
1
;
Zhen YANG
1
;
Wanhua REN
1
Author Information
1. Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, China
- Publication Type:Reviews
- Keywords:
Bile Duct Neoplasms;
Ferroptosis;
Pathologic Processes
- From:
Journal of Clinical Hepatology
2022;38(4):951-955
- CountryChina
- Language:Chinese
-
Abstract:
The incidence and mortality rates of cholangiocarcinoma (CCA) are increasing constantly, and it is of great importance to explore new therapeutic targets. Ferroptosis, a unique pattern of cell death caused by iron-dependent cellular oxidative injury, is closely associated with iron metabolism and oxidative stress imbalance in cancer and has become a research hotspot in the field of tumor. This article introduces the mechanism of ferroptosis and the research advances in ferroptosis involved in the development and progression of CCA, and it is pointed out that the regulatory mechanism of ferroptosis has an important clinical value in the malignant progression of CCA.
