Genetic studies of primary biliary cholangitis in the post-GWAS era
10.3969/j.issn.1001-5256.2022.04.005
- VernacularTitle:后GWAS时代的原发性胆汁性胆管炎的遗传学研究
- Author:
Fang QIU
1
;
Chan WANG
2
;
Mingming ZHANG
3
;
Xingjuan SHI
3
;
Xiangdong LIU
3
Author Information
1. Department of Clinical Laboratory, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing 210031, China
2. Research Institute of Translational Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China
3. School of Life Science and Technology, Southeast University, Nanjing 210096, China
- Publication Type:Discussions by Experts
- Keywords:
Primary Biliary Cholangitis;
Genetics;
Genome-Wide Association Study
- From:
Journal of Clinical Hepatology
2022;38(4):759-761
- CountryChina
- Language:Chinese
-
Abstract:
With the constant increase in the awareness of primary biliary cholangitis (PBC) and the continuous improvement in related diagnostic methods in the past two decades, the incidence and prevalence rates of PBC tend to increase and PBC is now the most common autoimmune liver disease worldwide. A series of family-based studies in the early stage have shown that PBC has strong genetic tendency, and subsequent genomic analyses have been performed for PBC in different populations and have obtained a large amount of genetic data. Future genetic studies of PBC will focus on translating these results into clinical practice.
