Preparation of cinnamaldehyde loaded liposomes bilayer-modified by bovine serum albumin/chitosan
- VernacularTitle:牛血清白蛋白/壳聚糖双层修饰载肉桂醛脂质体的制备
- Author:
Zheng WEI
1
,
2
,
3
;
Sen YANG
1
,
2
,
3
;
Zhengkang LUO
1
,
2
,
3
;
Ou SHA
4
;
Zhidan LUO
1
,
2
,
3
;
Jian ZHANG
1
,
2
Author Information
1. School of Pharmacy，Jiangsu Ocean University，Jiangsu Lianyungang 222005，China
2. Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening，Jiangsu Lianyungang 222005，China
3. Co-innovation Center of Jiangsu Marine Bio-industry Technology，Jiangsu Lianyungang 222005，China
4. School of Environment and Chemical Engineering，Jiangsu Ocean University，Jiangsu Lianyungang 222005，China
- Publication Type:Journal Article
- Keywords:
liposomes;
cinnamaldehyde;
bovine serum albumin;
chitosan;
sustained release;
stability
- From:
China Pharmacy
2022;33(7):848-852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To prepare cinnamaldehyde （CA） loaded liposomes bilayer-modified by bovine serum albumin （BSA）/chitosan （CTS）（BSA/CTS-Lip-CA） in order to improve the sustained-release effect and storage stability of the nanoparticles. METHODS Firstly，cinnamaldehyde loaded liposomes （Lip-CA）and blank liposomes （Lip-Blank）were prepared by thin film dispersion method. Then chitosan modified cinnamaldehyde loaded liposome （CTS-Lip-CA）and BSA/CTS-Lip-CA were obtained by electrostatic adsorption. Finally ， the prepared liposomes were characterized ， and their in vitro release characteristics and storage stability were investigated. RESULTS The particle size of BSA/CTS-Lip-CA was （177.8±4.0）nm and the Zeta potential was （－15.6±1.5）mV；they were in spherical shape ；FTIR analysis showed that the modification of BSA and CTS had no effect on the internal structure of liposomes. The results of in vitro drug release characteristics showed that the cumulative release of Lip-CA ，CTS-Lip-CA and BSA/CTS-Lip-CA within 10 hours were 82.9％，74.1％ and 72.9％ respectively. The results of storage stability showed that after 30 days of storage ，the particle sizes of Lip-CA ，CTS-Lip-CA and BSA/ CTS-Lip-CA were （134.2±2.1），（151.7±0.4），（164.8±1.5）nm；the retention rates of model drug CA were 65.4％，82.5％ and 90.2％ respectively. CONCLUSIONS BSA/CTS-Lip-CA is successfully prepared. It has a certain sustained-release effect and can improve the storage stability of the drug to a certain extent.
