Study on quality standard of Jingtian Zhitong cream
10.12206/j.issn.1006-0111.202109050
- VernacularTitle:景天止痛膏质量标准研究
- Author:
Dan HU
1
;
Ming YIN
2
;
Xiwen WANG
1
;
Hong CAO
1
;
Guiying ZHANG
1
;
Chuanyang SU
1
;
Shuai ZHANG
1
Author Information
1. General Station for Drug and Instrument Supervision and Control, Joint Logistics Support Force of the PLA, Beijing 100166, China.
2. the Emergency Department of the Second Medical Center and National Clinical Research Center for Geriatric Diseases，ChinesePLA General Hospital, Beijing 100853, China.
- Keywords:
Jingtian Zhitong cream;
quality standard;
HPLC;
TLC
- From:
Journal of Pharmaceutical Practice
2022;40(2):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To revise the determination method in the quality standard of Jingtian Zhitong cream. Methods The total saponins of angelica sinensis, Ligusticum wallichii, Rhizoma corydalis, and Panax notoginseng saponins were qualitatively identified by thin-layer chromatography (TLC). The contents of notoginsenoside R1, ginsenoside Rg1, and ginsenoside Rb1 in the preparation were determined by high performance liquid chromatography (HPLC). Results TLC showed strong specificity and good resolution. The concentration of notoginsenoside R1 showed a good linear relationship in the range of 0.1604 and 2.0050μg (r=0. 999). The concentration of ginsenoside Rg1 showed a good linear relationship in the range of 0.8003 and 10.0035μg (r=1.000). The concentration of ginsenoside Rb1 showed good linearity in the range of 0.6182 and 7.7275μg (r=1.000). The sample recovery rates were 101.43%, 98.75% and 100.95%, respectively. The relative standard deviation (RSD) were 2.56%, 2.71% and 2.75%, respectively. Conclusion The developed method is accurate and reliable with high sensitivity, which can be used for the quality control of Jingtian Zhitong cream.
