The MAPK signaling pathway: A new target for the treatment of hepatic echinococcosis
10.3969/j.issn.1001-5256.2022.03.045
- VernacularTitle:MAPK信号通路——肝棘球蚴病治疗新靶点
- Author:
Linlin DONG
1
;
Yongliang LU
2
;
Weijian E
2
;
Xiang ZHANG
2
;
Lingli ZHAO
2
Author Information
1. Qinghai University, Xining 810000, China
2. Department of Clinical Laboratory, The Affiliated Hospital of Qinghai University, Xining 810000, China
- Publication Type:Reviews
- Keywords:
Echinococcosis, Hepatic;
Mitogen-Activated Protein Kinases;
MAP Kinase Signaling System
- From:
Journal of Clinical Hepatology
2022;38(3):714-718
- CountryChina
- Language:Chinese
-
Abstract:
The MAPK signaling pathway can mediate a variety of cytokines to participate in the processes of inflammation, cancer, immune disorder, and neurodegenerative diseases, and it also plays an important role in the development and progression of hepatic echinococcosis. This article reviews the structure and regulation of the MAPK signaling pathway and elaborates on the role of the MAPK signaling pathway in hepatic echinococcosis. It is pointed out that the MAPK signaling pathway can activate both the cyst and the host in hepatic echinococcosis, participate in the development and progression of the disease, and exert an impact on its treatment. Drug therapy targeting the MAPK signaling pathway is expected to become a new strategy for the treatment of hepatic echinococcosis.
