Association between cholesterol and liver regeneration and its significance and potential value in clinical treatment of liver failure
10.3969/j.issn.1001-5256.2022.03.044
- VernacularTitle:胆固醇与肝再生关系及其在肝衰竭治疗中的意义和潜在价值
- Author:
Yong LIN
1
;
Gengjie YAN
1
;
Feng FENG
1
;
Ziming PENG
1
;
Fuli LONG
1
,
2
;
Ailing WEI
2
;
Minggang WANG
2
;
Chun YAO
3
Author Information
1. Graduate School of Guangxi University of Chinese Medicine, Nanning 530200, China
2. Second Ward of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
3. Guangxi University of Chinese Medicine, Nanning 530000, China
- Publication Type:Reviews
- Keywords:
Liver Failure;
Cholesterol;
Liver Regeneration
- From:
Journal of Clinical Hepatology
2022;38(3):708-713
- CountryChina
- Language:Chinese
-
Abstract:
Liver failure is a common severe liver disease syndrome in clinical practice and is one of the critical medical conditions in internal medicine. Massive hepatocyte death is the main pathological feature of liver failure, and its core mechanisms include endotoxin, immune response, and inflammatory cascade reaction. Effective regeneration of hepatocytes to compensate liver function is the physiological basis for promoting the good prognosis of liver failure, which directly affects the prognosis and quality of life of patients with liver failure. It has been found in clinical practice that liver failure patients with a low serum level of cholesterol tend to have an extremely high mortality rate, but as an index of hepatocyte anabolism, the association between cholesterol and hepatocyte regeneration has not been taken seriously. Based on the association between cholesterol and liver regeneration, this article reviews its significance and potential value in the clinical treatment of liver failure, in order to understand the pathogenesis of liver failure from another perspective and provide new ideas for the diagnosis and treatment of liver failure and the development of drugs.
