Role and potential clinical value of exosomes in the development and progression of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2022.03.041
- VernacularTitle:外泌体在肝细胞癌发生发展中的作用及潜在临床价值
- Author:
Yehao LUO
1
;
Donghan XU
2
;
Ting LYU
3
;
Tiejian ZHAO
1
;
Lei WANG
4
Author Information
1. Key Laboratory of Zhuang Medicine Prescriptions Basis and Application Research, Guangxi University of Chinese Medicine, Nanning 530200, China
2. School of Traditional Chinese Medicine, Macau University of Science and Technology, Macau, 999078, China
3. School of Medicine, Hubei University for Nationalities, Enshi, Hubei 445000, China
4. Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning 530200, China
- Publication Type:Reviews
- Keywords:
Exosomes;
Carcinoma, Hepatocellular;
Tumor Microenvironment
- From:
Journal of Clinical Hepatology
2022;38(3):693-697
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes have the dual characteristics of promoting and inhibiting cancer and can induce the proliferation, invasion, and metastasis of hepatoma cells by altering tumor microenvironment, promoting neovascularization, and regulating epithelial-mesenchymal transition. Exosomes can regulate hepatocellular carcinoma and inhibit the growth and metastasis of hepatoma cells by regulating a variety of physiological and pathological processes, thus playing an important role in clinical diagnosis and treatment. It is pointed out that exosomes may become an effective antitumor treatment method through immune regulation and remodeling of tumor microcirculation.
