Mechanism of action and clinical significance of hypoxia-inducible factors in hepatocellular carcinoma
10.3969/j.issn.1001-5256.2022.03.040
- VernacularTitle:缺氧诱导因子对肝细胞癌的作用机制及临床意义
- Author:
Hongyi LI
1
;
Yehao LUO
1
;
Xiaofan LUO
1
;
Di WU
1
;
Huangguan QIN
1
;
Saohang LAN
1
;
Ting LYU
2
;
Yuzhou PANG
1
Author Information
1. Key Laboratory of Applied Basic Research of Guangxi Zhuang Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China
2. Department of Medicine, Hubei Minzu University, Enshi, Hubei 445000, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Hepatocellular;
Hypoxia-Inducible Factor;
Molecular Targeted Therapy;
Prognosis
- From:
Journal of Clinical Hepatology
2022;38(3):688-692
- CountryChina
- Language:Chinese
-
Abstract:
Due to the rapid proliferation and growth of tumor cells, hypoxic microenvironment exists in many solid tumors, and hypoxia inducible factors (HIF) are critical for sensing oxygen tension within tumors and subsequently mediating the activation of hypoxia responses. Hepatocellular carcinoma (HCC) is one of the most hypoxic tumors. This article summarizes the mechanism of action of HIF in promoting the development and progression of HCC by promoting glycolysis, angiogenesis, invasion and metastasis, immune escape, and cancer stem cell formation. At present, the development of targeted drugs for HIF inhibitors has broad prospects in the treatment of HCC, and the detection of HIF also has a potential value in prognostic evaluation HCC.
