Role of lysyl oxidase family in the development and progression of hepatocellular carcinoma
10.3969/j.issn.1001-5256.2022.03.039
- VernacularTitle:赖氨酰氧化酶家族在肝细胞癌发生发展中的作用
- Author:
Xiaobin QIN
1
;
Zulong LI
1
;
Shenglan ZENG
1
;
Liting TAN
1
;
Yingyu LE
1
;
Dewen MAO
2
Author Information
1. Graduate School of Guangxi University of Chinese medicine, Nanning 530021, China
2. Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
- Publication Type:Reviews
- Keywords:
Carcinoma, Hepatocellular;
Protein-Lysine 6-Oxidase;
Drugs, Chinese Herbal
- From:
Journal of Clinical Hepatology
2022;38(3):682-687
- CountryChina
- Language:Chinese
-
Abstract:
Lysyl oxidase (LOX) family is a group of copper-containing amine oxidases composed of LOX and LOX-like proteins (LOXL1, LOXL2, LOXL3, and LOXL4). It is overexpressed in tumor tissue and promotes tumor metastasis through covalent cross-linking of extracellular matrix, with the functions of cell growth control, tumor inhibition, senescence, and chemotaxis. In recent years, more and more evidence has shown that LOX family members play a key role in the pathogenesis of hepatocellular carcinoma (HCC), suggesting that they have great potential as therapeutic targets. This article reviews the role of LOX family members in the development and progression of HCC and the intervention effect of traditional Chinese medicine extracts on HCC by regulating LOX family, in order to provide a reference for further research on the prevention and treatment of HCC.
