Research process of reactive oxygen species-based tumor immunomodulation
10.16438/j.0513-4870.2021-1501
- VernacularTitle:基于活性氧的肿瘤免疫调控研究进展
- Author:
Fan-xue BU
;
Yu-zhao ZHENG
;
Jian-ping ZHOU
;
Ting-jie YIN
- Publication Type:Research Article
- Keywords:
reactive oxygen species;
oxidative stress;
immune response;
tumor;
immunomodulation
- From:
Acta Pharmaceutica Sinica
2022;57(2):296-302
- CountryChina
- Language:Chinese
-
Abstract:
Reactive oxygen species (ROS) is defined as the electron reduction product of oxygen with high reactivity which can maintain normal physiological functions and redox homeostasis. The tumor microenvironment is in a state of oxidative stress. ROS can affect multiple processes of tumor immune response by modulating the phenotype and functions of tumor cells and immune cells. With the rapid development of immunology, ROS-based tumor immunomodulation has been widely concerned and studied. In this review, the mechanism of ROS participating in tumor immune response is elaborated. Meanwhile, the research process and application of ROS in tumor immunomodulation in recent years are reviewed and analyzed.
