Two new triterpenes from Maytenus guangxiensis with their antiproliferative activity
10.16438/j.0513-4870.2021-1483
- VernacularTitle:广西美登木中两个新的三萜类化合物及其抗肿瘤活性
- Author:
Yuan-yuan HUANG
;
Xue-gong JIA
;
Fu-sheng DENG
;
Jing-ya MO
;
Jing-quan YUAN
- Publication Type:Research Article
- Keywords:
italic>Maytenus guangxiensis;
triterpenoids;
cytotoxic activity
- From:
Acta Pharmaceutica Sinica
2022;57(2):441-445
- CountryChina
- Language:Chinese
-
Abstract:
Four triterpenoids were isolated and purified from the 95% ethanol extract of Maytenus guangxiensis by silica gel column chromatography, Sephadex LH-20 column chromatography, MCI column chromatography and preparative RP-HPLC. Their structures were determined from their physicochemical properties and spectral data. They were identified as maytguanone A (1), maytguanone B (2), 11α-methoxyurs-12-ene-1β,3β-diol (3), lup-20(29)-ene-3β,11α-diol (4). Compounds 1 and 2 are new triterpenoids, along with compounds 3 and 4 were isolated from M. guangxiensis for the first time. The cytotoxicity of compounds 1, 3 and 4 was evaluated using the MTT procedure with three cancer cell lines. The results show that compound 3 displayed good inhibitory effects against HeLa, with an IC50 of 10.68 μmol·L-1.
