Research progress of Nrf2 inhibitor in tumor therapy

VernacularTitle:Nrf2抑制剂在肿瘤治疗中的研究进展
Author: Yi MOU ^{1
,

2} ; Yu SONG ^{1
,

2} ; Shuai WEN ^{1
,

2} ; Yan WANG ^{1
,

2} ; Zheng-yu JIANG ³
Author Information

1. College of Pharmacy and Chemistry &
2. Chemical Engineering, Taizhou University, Taizhou 225300, China
3. Jiangsu Key Laboratory of Drug Design and Optimization, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Publication Type:Research Article
Keywords: Nrf2; tumor; chemotherapy for cancer; inhibitors
From: Acta Pharmaceutica Sinica 2022;57(2):321-330
CountryChina
Language:Chinese
Abstract: Nrf2 is a multi-effect transcription factor, which plays a crucial role in cytoprotective system. With the deepening of research on new regulatory modes and biologic functions of Nrf2, the oncogenic role of Nrf2 in malignant transformed tumors is increasingly obvious. More and more evidences show that Nrf2 is involved in the whole process of tumor occurrence, development, metastasis and prognosis, and inhibiting Nrf2 may be a promising strategy in tumor therapy. However, the development of Nrf2 inhibitors is still in early stage. In this paper, the biological function of Nrf2 and its dual role in tumor are briefly introduced, and representative Nrf2 inhibitors are reviewed according to their structure types, so as to provide reference and ideas for the development of anti-tumor drugs centering on the regulation of Nrf2.