Research advances in new technologies in targeted protein degradation
10.16438/j.0513-4870.2021-1249
- VernacularTitle:靶向蛋白质降解的新兴技术及其研究进展
- Author:
Jing-hong LIU
;
Yi-min CHEN
;
Xiao-qing CAI
- Publication Type:Research Article
- Keywords:
targeted protein degradation;
proteolysis-targeting chimera;
lysosome-targeting chimera;
autophagy-targeting chimera;
autophagosome-tethering compound;
chaperone-mediated autophagy
- From:
Acta Pharmaceutica Sinica
2022;57(2):313-320
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the targeted protein degradation technology has developed quickly, with proteolysis-targeting chimera (PROTAC) as the best-known strategy through exploring the ubiquitin-proteasome system. A number of new targeted protein degradation strategies have been emerging to expand the scope of protein degradation technology, including lysosome-targeting chimeras (LYTACs), autophagy-targeting chimeras (AUTACs), autophagosome-tethering compounds (ATTECs) and chimeras based on chaperone-mediated autophagy (CMA). The emerging methodologies have explored another important protein degradation system in eukaryotes-lysosomal systems, such as the endosome-lysosome pathway and the autophagy-lysosome pathway. This review summaries the mechanisms and features of different strategies for targeted protein degradation, with a special emphasis on the new targeted protein degradation technologies, such as their current status, advantages and limitations.
