Sesquiterpenoids and iridoids from <italic>Valeriana jatamansi </italic>with anti-inflammatory and anti-influenza virus properties

VernacularTitle:蜘蛛香中的倍半萜和环烯醚萜类成分及其抗炎和抗流感病毒活性
Author: Dao-qun SHI ; Yun WANG ; Kai-rui RAO ; Na JIANG ; Dan LIU ; Rong-tao LI ; Hong-mei LI
Publication Type:Research Article
Keywords: italic>Valeriana jatamansi Jones; sesquiterpenoid; iridoid; anti-inflammatory; anti-influenza virus
From: Acta Pharmaceutica Sinica 2022;57(2):428-432
CountryChina
Language:Chinese
Abstract: Three sesquiterpenoids and nine iridoids were isolated from the roots and rhizomes of Valeriana jatamansi by various chromatographic methods. Their structures were identified by physicochemical properties, NMR and MS data. Among them, valeriananoid G (1) was a new patchoulol-type sesquiterpenoid, and compound 3 was isolated from the genus Valeriana for the first time. Compounds 3 and 10 exhibited significant inhibitory effects on nitric oxide production induced by lipopolysaccharide in RAW 264.7 macrophages, with IC₅₀ values of 19.00 and 3.66 μmol·L^-1, respectively. In addition, compounds 4, 6 and 12 showed anti-influenza virus activity with IC₅₀ values of 51.75, 51.40 and 102.08 μmol·L^-1, respectively.