A study on the rapidly non-destructive detection method of Huoxiang Zhengqi oral liquid using near infrared spectroscopy
10.16438/j.0513-4870.2021-0817
- VernacularTitle:基于近红外光谱技术的藿香正气口服液质量透瓶快速检测方法研究
- Author:
Qian LI
1
;
Le-ting SI
1
;
Yan-qin HE
1
;
Jun WANG
2
;
Tao PENG
3
;
Zi-liang DONG
3
;
Yong-jiang WU
1
Author Information
1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
2. Suzhou Zeda Xingbang Pharmaceutical Technology Co., Ltd., Suzhou 215000, China
3. Taiji Group Chongqing Fuling Pharmaceutical Factory Co., Ltd., Chongqing 408099, China
- Publication Type:Research Article
- Keywords:
near-infrared spectroscopy;
non-destructive testing;
quantitative analysis;
Huoxiang Zhengqi oral liquid;
traditional Chinese medicine
- From:
Acta Pharmaceutica Sinica
2022;57(2):453-459
- CountryChina
- Language:Chinese
-
Abstract:
Based on near infrared spectroscopy and high performance liquid chromatography, this paper established the regression relationship between near infrared spectroscopy and index component content of Huoxiang Zhengqi oral liquid, so as to realize the rapid detection of index component content based on near infrared spectroscopy. Magnolol, honokiol and hesperidin were used as the quality indexes of Huoxiang Zhengqi oral liquid. After using the first derivative and normalization pretreatment method, characteristic variables were screened by CARS, and the correction model was finally established by partial least-squares regression (PLSR) method. The method accuracy was evaluated with the external validation, and the prediction results were tested for significance. The results indicated that when the near infrared spectrum was scanned through the bottle, the model's correlation coefficients of prediction (Rp) were higher than 0.99, the root mean square errors of the prediction models (RMSEP) were all less than 0.008 4, and the relative standard errors of prediction set (RSEP) were all less than 2.83%. There was no significant difference in the predicted results between these two kinds of model. The models established in the non-destructive way have good performance and high prediction accuracy. The rapid and nondestructive way has application value in the quality control of Huoxiang Zhengqi oral liquid.
