Chemical constituents of soft coral Sarcophyton glaucum collected from Xisha and their anti-inflammatory activity
10.16438/j.0513-4870.2021-1292
- VernacularTitle:西沙乳白肉芝软珊瑚中的化学成分及其抗炎活性研究
- Author:
Jin-feng LI
1
,
2
,
3
;
Li-gong YAO
4
;
Yan-bo ZENG
1
,
3
;
Yue-wei GUO
4
,
5
Author Information
1. Ocean College of Hebei Agricultural University, Qinhuangdao 066000, China
2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
3. Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
4. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
5. Bohai rim Advanced Research Institute for Drug Discovery, Yantai 264000, China
- Publication Type:Research Article
- Keywords:
soft coral;
italic>Sarcophyton glaucum;
iterpenoid;
15-dehydroxy-sarcophytol D;
anti-inflammatory activity
- From:
Acta Pharmaceutica Sinica
2022;57(3):741-749
- CountryChina
- Language:Chinese
-
Abstract:
The crude Et2O extract of soft coral Sarcophyton glaucum, collected off the Xisha, the South China Sea, were investigated. A new cembrane-type diterpenoid, namely 15-dehydroxy-sarcophytrol D (1), together with twenty-five known compounds, namely ximaoglaucumin C (2), (11S,12S,1E,3E,7E)-11,12-epoxycembra-1,3,7-triene (3), sarcophytol W (4), cembrene (5), sarcophytol B (6), sarcophytol K (7), sarcophytol J (8), pentaene-cembrene (9), sarcophytol E (10), (+)-marasol (11), (2S)-sarcophytoninsarcophytoxide (12), (-)-17-hydroxydeepoxysarcophytoxide (13), (+)-sarcophytoxide (14), 13-acetoxysarcophytoxide (15), bophynin B (16), 16-oxosarcophytoxide E (17), sarcophinone (18), 7α-8β-dihydroxydeepoxysarcophine (19), (+)-sarcophine (20), 14-dehydroxy-sarcophytol L (21), sarcophytol L (22), 13α-hydroxy-sarcophytol L (23), trocheliophol C (24), trocheliophol E (25) and trocheliophol L (26), were isolated and purified by comprehensive chromatography methods of silica gel column, Sephadex LH-20 gel column, TLC, and semi-preparative high-performance liquid chromatography (HPLC). In anti-inflammatory bioassay, compound 4 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in BV-2 microglial cells.
