Recent advances on cancer-associated fibroblasts treatment strategies and delivery systems
10.16438/j.0513-4870.2021-0848
- VernacularTitle:肿瘤相关成纤维细胞治疗策略及其递送系统研究进展
- Author:
Shi-jun YUAN
;
Yong-jun LIU
;
Na ZHANG
- Publication Type:Research Article
- Keywords:
cancer-associated fibroblast;
nano-carrier;
rug delivery;
physical barrier;
cancer therapy
- From:
Acta Pharmaceutica Sinica
2022;57(3):638-643
- CountryChina
- Language:Chinese
-
Abstract:
A large number of cancer-associated fibroblasts (CAFs) in tumor tissues create a favorable environment for the development of tumor. CAFs inhibit immune cells activation and viability by cytokine secretion, and CAFs prohibit drugs and immune cells infiltration by producing extracellular matrix to weaken cancer treatment efficacy. Regulating CAFs or overcoming CAFs barriers are new strategies for cancer therapy. Hence, designing nano-carriers for regulating CAFs to suppress tumor progression or promoting drug delivery to tumor site by overcoming CAFs barriers has attracted much attention. Therefore, this manuscript reviewed the recent progresses of nano-carriers for CAFs-targeting cancer therapies, in order to provide a reference for clinical cancer treatment.
